Our clinical-strength 1000mg Tru Niagen Pro is the most researched daily serving, clinically proven to increase NAD+ by up to 150% and maintain elevated levels with daily supplementation.
Formerly exclusive to physicians and athletes, this potent serving helps support whole-body cellular energy to optimize daily vitality and healthy aging.
Our key ingredient, Niagen, is backed by world-leading researchers, currently featured in more than 65% of registered, ongoing, or completed trials on nicotinamide riboside (NR).²
Made in the U.S. with globally sourced components.
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- Take two 500mg capsules daily as needed or as recommended by your healthcare professional.
- Tru Niagen Pro 1,000mg is meant to be taken daily. 1,000mg of Niagen® is clinically proven to increase NAD+ levels by up to 150% in as little as three weeks.
- 1,000mg is the most commonly used serving in published clinical studies, and has been researched at servings as high as 2,000mg per day.²
- There is no evidence that more Niagen® has any adverse effects.
- Niagen®, our patented nicotinamide riboside, is the research-grade NAD+ precursor trusted by 65% of clinical studies.²
- As one of the most well-researched NAD+ supplements available, Niagen® increases NAD+ more efficiently than other NAD+ precursors and supplements.
- Our clinical-strength 1,000mg daily serving delivers proven NAD+ increases up to 150% to support optimal cellular function, energy production, and cellular repair.
- Formerly exclusive to physicians and professional athletes, this potent formula supports cellular health, brain function, muscle health, and heart health†.
- Supports healthy aging and enhanced cellular resilience for those with active lifestyles, age-related concerns, and additional lifestyle stressors.
- Niagen is routinely used in published peer-reviewed studies. When researchers demand results, they choose our proven formula.

Niagen®
Our patented, safety-reviewed form of nicotinamide riboside (NR). One of the most well-researched, efficacious, and clinically proven NAD+ precursors available. Shown to easily pass through your cell walls, Niagen facilitates NAD+ production more efficiently than any other NAD+-boosting supplements or precursors.
Vegetarian
NSF Certified for Sport
FDA-Notified
Formulated without gluten
Formulated without allergens
Safety-tested
Kosher
Halal

"Tru Niagen has been a wonderful supplement that I need in order to be active, healthy and feeling unstoppable. At near 76 years old in two months, I believe that it makes me feel like I am aging backwards. It is remarkable how good I feel and how it has greatly improved my overall well-being."
"Tru Niagen has become a surprising addition to my wellness routine. After a couple of weeks, I noticed a subtle but real boost in [cellular] energy... not the jittery, coffee-fueled kind, but a steady, all-day vitality. It's like my cells got a wake-up call to stop slacking and start repairing!"
"Representing the gold-standard in NAD+ precursors, Tru Niagen is a staple in the supplement programs I recommend to the elite athletes I work with. Its safety, effectiveness, testing standards, and science stand out among other products on the market."
Tru Niagen Pro® 1,000mg
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Powered by Niagen®, this clinical-strength serving of our patented nicotinamide riboside (NR) is clinically proven to increase NAD+ levels, helping your cells produce more energy and support better aging. Get the Details
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Our clinical-strength 1000mg Tru Niagen Pro is the most researched daily serving, clinically proven to increase NAD+ by up to 150% and maintain elevated levels with daily supplementation.
Formerly exclusive to physicians and athletes, this potent serving helps support whole-body cellular energy to optimize daily vitality and healthy aging.
Our key ingredient, Niagen, is backed by world-leading researchers, currently featured in more than 65% of registered, ongoing, or completed trials on nicotinamide riboside (NR).²
Made in the U.S. with globally sourced components.
![]() |
![]() |
- Take two 500mg capsules daily as needed or as recommended by your healthcare professional.
- Tru Niagen Pro 1,000mg is meant to be taken daily. 1,000mg of Niagen® is clinically proven to increase NAD+ levels by up to 150% in as little as three weeks.
- 1,000mg is the most commonly used serving in published clinical studies, and has been researched at servings as high as 2,000mg per day.²
- There is no evidence that more Niagen® has any adverse effects.
- Niagen®, our patented nicotinamide riboside, is the research-grade NAD+ precursor trusted by 65% of clinical studies.²
- As one of the most well-researched NAD+ supplements available, Niagen® increases NAD+ more efficiently than other NAD+ precursors and supplements.
- Our clinical-strength 1,000mg daily serving delivers proven NAD+ increases up to 150% to support optimal cellular function, energy production, and cellular repair.
- Formerly exclusive to physicians and professional athletes, this potent formula supports cellular health, brain function, muscle health, and heart health†.
- Supports healthy aging and enhanced cellular resilience for those with active lifestyles, age-related concerns, and additional lifestyle stressors.
- Niagen is routinely used in published peer-reviewed studies. When researchers demand results, they choose our proven formula.

Niagen®
Our patented, safety-reviewed form of nicotinamide riboside (NR). One of the most well-researched, efficacious, and clinically proven NAD+ precursors available. Shown to easily pass through your cell walls, Niagen facilitates NAD+ production more efficiently than any other NAD+-boosting supplements or precursors.
Vegetarian
NSF Certified for Sport
FDA-Notified
Formulated without gluten
Formulated without allergens
Safety-tested
Kosher
Halal

"Tru Niagen has been a wonderful supplement that I need in order to be active, healthy and feeling unstoppable. At near 76 years old in two months, I believe that it makes me feel like I am aging backwards. It is remarkable how good I feel and how it has greatly improved my overall well-being."
"Tru Niagen has become a surprising addition to my wellness routine. After a couple of weeks, I noticed a subtle but real boost in [cellular] energy... not the jittery, coffee-fueled kind, but a steady, all-day vitality. It's like my cells got a wake-up call to stop slacking and start repairing!"
"Representing the gold-standard in NAD+ precursors, Tru Niagen is a staple in the supplement programs I recommend to the elite athletes I work with. Its safety, effectiveness, testing standards, and science stand out among other products on the market."
Whole-body benefits
From your daily routine to your biggest goals, Tru Niagen powers your cellular health, helping you thrive.

Replenish NAD+ daily to keep your cells energized, supported during repair, and resilient.

Support your hardworking brain cells with increased NAD+.

Supports cellular energy that your heart cells need.

Help fuel your muscle cells to support recovery and repair.

Support your 37.2 trillion cells by supporting cellular energy, metabolism, and repair.

Daily stressors can deplete NAD+, which can accelerate aging. Replenish NAD+ to support your health.
Backed by gold standard science, quality, and safety

Efficacy backed by peer-reviewed published research
Partnership with 200+ institutions: We partner with top institutions like Mayo Clinic, National Institute on Aging, Harvard, and Cambridge.
Backed by independent research: 94% of peer-reviewed, published Niagen® studies are investigator-driven and third-party funded.
A clinical trial published in The American Journal of Clinical Nutrition in 2018
Dollerup et al., 2018.
A clinical trial published in The American Journal of Clinical Nutrition in 2019
Elhassan et al., 2019.

Third-party verified for safety and quality
NSF Certified for Sport®
NSF’s Certified for Sport® is the only third-party certification recognized by United States Anti-Doping Agency (USADA), Major League Baseball (MLB), and the National Hockey League (NHL).
To earn this, supplements must meet strict quality standards, contain no unsafe contaminants, and be free of 270+ banned substances. Both Tru Niagen Stick Packs and Tru Niagen Pro are made in NSF-audited, GMP-certified facilities, with every batch verified for safety and transparency on NSF’s Certified for Sport® website.
Backed by 25 years of research & innovation
35+
Backed by peer-reviewed published studies.
2
Backed by a Scientific Advisory Board of world-leading researchers.
50+
Backed by innovation gold standards in the supplement space.
400+
NR is well-researched in published preclinical and clinical studies.
Reviews
Frequently Asked Questions
NAD+ (Nicotinamide Adenine Dinucleotide) is a crucial coenzyme found in every cell of your body that powers hundreds of metabolic processes. It serves as a key player in cellular energy production, DNA repair, and cellular communication. NAD+ works by transferring electrons during cellular metabolism, enabling your cells to convert nutrients into energy and supporting essential functions that keep your body running optimally.
NAD+ levels naturally decline from birth, accelerating around age 30, and dropping by up to 65% by age 70. Environmental and lifestyle stressors also diminish NAD+ levels, as do immune and health challenges. Taking a clinically proven supplement like Tru Niagen helps maintain your NAD+ baseline levels with daily use—to keep your body running smoothly as you age.
Tru Niagen is a superior choice compared to other NAD supplements because it contains Niagen®, our patented nicotinamide riboside (NR), a more bioavailable precursor to NAD+. Niagen® NR is backed by 35+ human clinical studies, and crosses cell membranes easily and is more efficiently converted into NAD+ inside cells, effectively boosting NAD+ levels.
This enhances energy metabolism, supports cellular repair, and promotes healthy aging, making Tru Niagen a more reliable, high-quality, pure, and potent option for raising NAD+ compared to other supplements. Tru Niagen® is clinically proven to increase NAD+ levels by over 50% with 300mg daily and by up to 150% with 1000mg daily and is backed by third-party quality-testing from NSF Certified for Sport and Alkemist Labs.
Most people report noticing improvements in cellular energy and overall wellbeing within 2-4 weeks of consistent daily use. However, the cellular health benefits of increased NAD+ levels begin immediately, even before you feel noticeable changes.
Clinical studies show that Tru Niagen begins elevating NAD+ levels within hours of taking your first dose, with significant increases observed within 2 weeks of daily supplementation. For optimal results, we recommend taking Tru Niagen consistently as part of your daily routine.
Tru Niagen has been rigorously tested for safety and is well-tolerated. Our proprietary key ingredient Niagen® has successfully completed multiple FDA safety reviews and is manufactured in cGMP-certified facilities in the USA.
Niagen is supported by 35+ clinical studies demonstrating its safety and efficacy. These human studies form the foundation of our scientific evidence. Over 65% of registered ongoing or completed nicotinamide riboside trials use Niagen.² Niagen is also backed by independent research, with over 90% of Niagen studies being investigator-driven and third-party funded.
In clinical studies, participants reported minimal to no side effects when taking the recommended dosage up to 2,000mg per day. Some individuals may experience mild and temporary effects that typically resolve quickly. As with any supplement, we recommend consulting with your healthcare provider before starting Tru Niagen, especially if you have existing health conditions or take medications.
Subscribers enjoy exclusive savings of 20% off every order, free shipping, and automatic delivery of Tru Niagen every month on your schedule. You can pause, skip, or adjust your subscription any time, risk-free. It’s the easiest way to ensure consistent NAD+ support for your daily health, while saving on every bottle.
Learn more about our Subscribe & Save program.
Tru Niagen Pro 1000mg is clinical strength, and the serving most often used in clinical studies. This product was formerly exclusive to physicians and pro athletes, and is now available to consumers who are seeking a higher serving of Niagen that is clinically proven to increase NAD+ levels by up to 150%.
Depending on your lifestyle and your age, we recommend working closely with your healthcare provider to determine the best serving size for your specific needs. You can also take our Product Quiz to see what serving might be right for you.
1000mg of Niagen is the most extensively researched daily dose, and the serving preferred in human clinical trials. Based on studies, Tru Niagen is safe for daily use at up to 2000mg.