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Our Science

A Supernutrient for Your Cells

Nicotinamide riboside is a groundbreaking ingredient that fuels your body from within.

Your health starts with your cells. Everything you do in life depends on the constant cycle of using and regenerating energy throughout your cells. Scientists have known for decades the importance of a coenzyme (a molecule that binds with proteins) called NAD+ (nicotinamide adenine dinucleotide) plays a vital role in the processes of your body. NAD+ helps create cellular energy and support cellular repair throughout your trillions of cells—and organs—throughout your body.

NR to NAD

Your NAD+ supply declines with age as well as in response to stressors on your body including alcohol consumption, intense exercise, and lack of sleep. However, in 2004, Dr. Charles Brenner discovered a naturally-occurring vitamin in milk called nicotinamide riboside. This micronutrient increases NAD+ levels by 40-50%.

While nicotinamide riboside can be found naturally in certain foods, you cannot get anywhere near the amount you need through a normal diet to effectively increase NAD+. That is why we created Tru Niagen®, the only patented, broadly studied, and safety-reviewed nicotinamide riboside in the world.

The objective proof behind Niagen® in 
11 published human clinical studies.

Our human clinical studies provide our foundation of scientific evidence. Researchers use Niagen® (patented nicotinamide riboside) as the preferred cellular nutrient for elevating NAD+ levels. Here are five of our studies, just to name a few.

A clinical trial published in Scientific Reports in 2019

Niagen® safely and effectively elevated NAD+ levels in healthy overweight adults.

A study published Nature Communications in 2018

Nicotinamide riboside safely and effectively elevated NAD+ levels in 60 healthy men and women aged 55-79.

A study published in Cell Reports in 2019

Nicotinamide riboside increased human skeletal muscle NAAD, a sensitive marker of increased NAD+ metabolism.

A study published in the American Journal of Clinical Nutrition in 2018

2000mg of daily nicotinamide riboside supplementation appeared safe and showed an increase in NAD+ metabolites in urine samples.

A study published in the American Journal of Clinical Nutrition in 2020

Nicotinamide riboside modestly improved body composition and acetyl carnitine (a fatty acid transporter) concentrations in skeletal muscle and increased metabolic rate during sleep.

Patented. Proven. Trusted. Safe.

3

FDA Safety Notifications

11

Published Human Clinical Studies

20 +

Owned and Licensed Patents

100 +

Preclinical Studies

200 +

Research Collaborations

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“The power of this form of vitamin B3 to raise NAD+ impressed me back in 2004 when I discovered it. Now, 14 years and 42 publications on NAD+ later, its unique ability to restore balance in the face of metabolic stress continues to amaze me.”

—Dr. Charles Brenner, PhD & ChromaDex Scientific Advisory Board Member 

The Scientist Who Discovered and Patented Nicotinamide Riboside while at Dartmouth University

Graph showing 300mg of Tru Niagen vs placebo Graph showing 300mg of Tru Niagen vs placebo Graph showing 300mg of Tru Niagen vs placebo


A new clinical study shows that Niagen® safely and effectively elevates NAD+ levels.

140 healthy and overweight adults were chosen at random to take NIAGEN® or a placebo for eight weeks. The study proves Niagen® (300mg daily) increases NAD+ levels by 40-50%.

Graph showing 300mg of Tru Niagen vs placebo Graph showing 300mg of Tru Niagen vs placebo Graph showing 300mg of Tru Niagen vs placebo

Explore the Science In Our Blog

What is a coenzyme? Why is NAD+ important? Learn more from our blog to help better understand the core of our product. We take complex science and distill it down to everyday language, enriching you with knowledge on cellular health.

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What Is NAD+?
Understand the inner workings behind this coenzyme and why it’s important for your health.
Explore
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What Is Nicotinamide Riboside?
Explore the groundbreaking micronutrient behind Tru Niagen®.
Explore

Learn More About NAD+ Research

Explore the latest groundbreaking science behind NAD+ and ongoing research. 

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Cellular Resilience for Life*