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Most NAD+ skincare products have a problem they don't talk about: NAD+ precursors are unstable in water. By the time a traditional liquid serum reaches your skin, much of the active ingredient has already degraded into generic niacinamide—a completely different compound with different properties. You think you're getting NAD+ science. You're largely getting a commodity ingredient.
Niagen NanoCloud™ sachets were designed from the ground up to solve that problem.
From the Niagen Skincare Innovation Lab—Niagen Bioscience's dedicated R&D program for translating the science behind Tru Niagen supplements into visible skin benefits—the NanoCloud sachet is the first and only skincare format powered by patented Niagen® (nicotinamide riboside chloride). It's not a repositioned serum or a niacinamide product with an NAD+ story layered on top. It is a fundamentally different delivery format, built around the stability requirements of Niagen from the ground up.
The Problem With NAD+ Skincare—And How Niagen NanoCloud Solves It
The challenge with including nicotinamide riboside in traditional skincare is stability. In water-based formulas, NAD+ precursors begin to degrade as soon as they contact water, acidic ingredients like vitamin C or AHAs, and the pH fluctuations that are common in traditional skincare manufacturing. By the time a conventional liquid product reaches your skin, the ingredient may have already broken down—leaving a fraction of what was originally included in the formula.
The solution is the NanoCloud sachet itself. Each NanoCloud sachet is a dry, waterless blend housed in a sealed, single-use format. The ingredients—Niagen included—remain protected and stable inside the sachet until you add your water-based serum or moisturizer to activate it. At that moment, the nanofiber matrix (made from pullulan and hyaluronic acid, natural biodegradable ingredients produced through fermentation) dissolves completely, delivering a freshly activated, full-potency dose to your skin.
You're not simply using a serum that's been degrading since it was manufactured. You're activating a precision dose of Niagen-powered skincare at peak potency, every single time.
Inside the Formula: What's in Each Niagen NanoCloud™ Sachet
Each NanoCloud sachet contains five ingredients, each with a specific role in the formula.
Niagen® (Patented Nicotinamide Riboside Chloride)
The same patented form of vitamin B3 that made Tru Niagen the gold standard in NAD+ supplementation—now formulated for topical use for the first time. The NanoCloud sachet's waterless format keeps Niagen stable and protected until activation, designed to deliver the ingredient at peak potency.
Sodium Hyaluronate
A low-molecular-weight form of hyaluronic acid that delivers hydration beyond the surface. Sodium hyaluronate draws moisture to the skin and supports a supple, cushioned feel throughout the day.
Pullulan
A natural polysaccharide derived through fermentation, pullulan forms a breathable film on skin that helps smooth texture, refine appearance, and create an instantly more lifted, polished look. It also forms the nanofiber matrix that encapsulates and protects Niagen inside each NanoCloud sachet.
Squalane
A bio-identical emollient that closely mimics your skin's natural lipids. Lightweight and non-greasy, squalane supports all-day softness and helps the skin barrier retain moisture.
Tocopherol (Vitamin E)
An antioxidant that helps protect skin from environmental stressors while supporting barrier health and resilience.
No parabens, sulfates, phthalates, or synthetic fragrances. Dermatologist-tested. Suitable for all skin types.
What the Research Found: Citruslabs Consumer Perception Study Results
We don't launch products on promises. Before Niagen NanoCloud sachets became available to the public, we ran a 6-week consumer perception study through Citruslabs to understand how real users experienced the formula.
Study overview: 40 participants enrolled, 37 completed. All female, ages 35+, twice-daily application for 6 weeks. Participants self-reported concerns including fine lines, wrinkles, hyperpigmentation, dark spots, redness, visible pores, and rough skin texture.
Real results, starting in as little as 2 weeks.
In just 2 weeks, over half of participants were already satisfied with their overall skin appearance—up from just 15% at baseline—a jump of more than 35 percentage points. Results continued to climb at every subsequent checkpoint through the end of the study.
By week 6:
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Nearly 3 out of 4 reported smoother, more moisturized skin.
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2 out of 3 said their skin texture had improved.
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3 out of 5 said their skin feels firmer and tighter.
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3 out of 4 wanted to continue using the product.
The baseline story is equally compelling.
The raw agreement rates are meaningful, but the improvement from baseline tells an even stronger story. For youthful-looking appearance, the peak result was seen at week 4, when 7 out of 10 participants agreed their skin appeared more youthful.*
Nearly 76% of participants wanted to keep using the product.
*Based on a 6-week consumer perception study of female participants aged 35+ (Fitzpatrick I/III/IV) who applied the product twice daily; 40 enrolled, 37 completed. Week 2 results (n=40); Week 4 and Week 6 results (n=37). Combined agree/strongly agree responses on a 5-point Likert scale. Percentage point change calculated from baseline (15%) to Week 2 (over 50% of participants). Individual results may vary.
This Is a Limited Release—Here's What That Means
Niagen NanoCloud™ is the first release from the Niagen Skincare Innovation Lab—our dedicated program for solving what most NAD+ skincare products get wrong. This is not a wide commercial launch. It's a small-batch innovation for the community closest to our science.
The limited format is intentional: it lets us listen, learn, and evolve. Every person who tries Niagen NanoCloud and shares their experience is directly shaping what the Skincare Innovation Lab builds next. Once this run is gone, we go back to the lab with your insights to refine and advance the formula.
You're not just trying a new product. You're part of how we innovate.
How to Use Niagen NanoCloud
Precision matters here. The Niagen NanoCloud sachet is a water-activated treatment designed to integrate with your existing skincare—not replace it.
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With dry hands, place one NanoCloud sachet in the palm of your hand.
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Add a dime-sized amount of your favorite water-based serum or moisturizer directly onto the NanoCloud sachet.
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Rub together until a smooth, gel-like consistency forms.
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Apply evenly to clean face and neck, avoiding the eye area.
Frequency: Use 1–2x daily, morning or night. Twice daily for optimal results.
Pro tip: Adjust the amount of serum or moisturizer to customize texture—more for a lighter, serum-like finish; less for a more concentrated treatment.
For a complete inside-out approach: Pair the NanoCloud sachet with Tru Niagen Beauty for Niagen-powered skin, hair, and nail support at the cellular level, from within.
Quality Standards That Matter
Every Skincare Innovation Lab product is held to the same standards that made Tru Niagen the most trusted name in NAD+ supplementation.
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We test Niagen levels throughout shelf life—something only required for OTC drugs, not cosmetics. We do it anyway.
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No parabens, sulfates, phthalates, or synthetic fragrances.
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Dermatologist-tested.
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Clean, fully transparent ingredient list—no proprietary blends.
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Developed by the team behind 40+ published studies on oral-grade Niagen NR.
The Tru Niagen Standard, Now for Your Skin
The same scientific integrity that underpins every Tru Niagen supplement guided the development of the NanoCloud sachet. We didn't reformulate a generic serum or badge an existing product with an NAD+ story. We built a new format around the stability requirements of Niagen®—because ingredient potency at the moment of application is the foundation of any effective skincare formula.
That's the Niagen Skincare Innovation Lab standard: ingredient purity, precision delivery, and complete transparency at every step.
Ready to experience NAD+ skincare at peak potency? Shop Niagen NanoCloud™ sachets or explore our complete product line to build your personalized NAD+ support routine, inside and out.