Tru Niagen is a breakthrough NAD-boosting supplement based on decades of scientific research designed to support your body at the cellular level. Its key active ingredient, nicotinamide riboside (NR), is a patented and FDA-notified form of vitamin B3 that helps your body naturally boost NAD+ – a vital molecule your cells need to function at their best.

Tru Niagen sets the gold standard in scientific rigor, safety, quality, and transparency. It's backed by one Nobel Prize winner, 45+ human clinical studies, and 500+ published scientific studies, and has been accepted by the world’s most rigorous regulatory bodies.

It's also trusted by customers worldwide as a simple daily step to help your cells stay strong, energized, and ready to meet life’s demands.

Want to learn more? Click here to dive deeper into what sets us far apart from the competition.

We recommend to start with a daily serving of 300mg of our Niagen nicotinamide riboside, which will increase NAD+ levels. Research also shows it’s safe to take up to 2000mg per day – a level demonstrated in clinical trials to effectively increase NAD+ and support NAD+ benefits in humans.

Our Tru Niagen 500mg Pro product was formulated initially exclusively for physicians and athletes and is now available for those who want to increase their NAD+ support, and is great for active lifestyles and healthy-aging enthusiasts. While future studies may inform new dosage guidance, this is what science supports today.

As always, we recommend checking in with your healthcare provider before making changes to your routine.

Tru Niagen is safe for most dietary needs. Our NAD+ products are made without the following: Dairy, Fish, Eggs, Shellfish, Peanuts, Corn, Tree Nuts, Latex, Soy, Gluten, Animal Byproducts, and Artificial Colors and Flavors.

Every body is unique, so your experience with Tru Niagen may look a little different depending on factors like age, diet, exercise, and sleep. What we do know is that Tru Niagen starts working quickly – boosting NAD+ levels soon after you begin taking it, and keeping them elevated with consistent daily use.

Some people notice more supported cellular energy and recovery, or simply feeling more resilient over time. Others may not “feel” something specific right away – and that’s perfectly normal. Tru Niagen's NAD+ supplement is still working behind the scenes, supporting your cells so they can stay strong, energized, and better equipped to handle the daily stresses of life.

Think of it as investing in your long-term cellular health. With daily use, you’re helping give your body the support it needs today – and setting yourself up better for tomorrow.

While we don’t have published human studies on how our Tru Niagen NAD+ supplements and alcohol interact, there’s no specific reason to avoid consuming them at the same time. That said, everyone’s body is different, so we always recommend checking in with your healthcare provider before starting any new supplement.

Yes, absolutely! You can take Tru Niagen’s NAD+ supplements alongside a standard multivitamin—even ones that contain vitamin B3. Tru Niagen’s key ingredient, nicotinamide riboside, is a special form of vitamin B3 that works differently from the niacin or nicotinamide found in most multivitamins. It’s uniquely absorbed by your cells and efficiently converted into NAD+, helping to power your body’s natural energy and repair processes.

As always, we recommend checking the label and talking with your healthcare professional if you have any questions.

Yes! Tru Niagen's NAD+ supplements have no known negative interactions with NSAIDs. Still, as with any new supplement, we always recommend consulting your healthcare practitioner prior to beginning use.

Currently, our products are designed with adult cellular health in mind. While there’s no evidence suggesting it’s harmful for younger individuals, it isn’t intended for use by children. As research on NAD+ continues to grow, more studies will be needed before we can provide guidance for those under 18.

There’s currently no evidence to suggest that taking Tru Niagen’s NAD+ supplement while breastfeeding poses any risks. However, because every body and journey are unique, we always recommend checking with your doctor before starting any new supplement.

Our key ingredient, Niagen®, is a nature-identical, synthesized form of a special vitamin B3 called nicotinamide riboside (NR). That means it’s made to be exactly the same—both structurally and functionally—as the NR found naturally in small amounts in foods like milk.

No negative effects have been reported in published clinical trials of Tru Niagen's NAD+ supplements. As with any supplement, if you ever feel any discomfort or notice side effects, it’s best to stop taking it and check in with your healthcare provider.

Every cell in your body is fueled by NAD+, a vital coenzyme that fuels cellular energy and repair throughout your entire body. NAD+ levels naturally decline with age (up to 65% between ages 30 and 70!), so replenishing NAD+ levels is essential for maintaining your cellular health, energy, and vitality.

Tru Niagen is a revolutionary supplement backed by decades of research and is clinically proven to increase NAD+ up to 150% with 1000mg daily to keep your cells performing at their best.



Powered by Niagen®, our patented form of nicotinamide riboside (a unique form of vitamin B3), Tru Naigen is one of the most well-researched, efficient, and superior NAD+ precursors available, ensuring you get the best for your health.

We're very proud to say that Tru Niagen stands at the forefront of NAD+ supplementation. It is backed by over 25 years of research in partnership with some of the brightest minds (including 1 Nobel Prize winner) and some of the most credible health institutions (300+ global research collaborations) in this area of science. It's one of the most well-researched supplements (500+ published scientific studies) on the market -- with over 60 patents covering the many revolutionary breakthroughs we've discovered.

Research continues worldwide, with ongoing studies exploring benefits for metabolism, neurological function, and healthy aging. Decades of rigorous science make Tru Niagen one of the most trusted NAD+ supplements on the market.

Niagen is the patented form of a nature-identical vitamin B3 known as nicotinamide riboside. Niagen is the key ingredient in Tru Niagen – which is the name of our product. Tru Niagen also contains other inactive ingredients in the capsule for processing.

NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme found in every living cell. It plays a central role in cellular energy production, helping your cells convert food into the energy your body needs to function. NAD+ also supports DNA repair, healthy metabolism, and cellular maintenance.

As we age, NAD+ levels naturally decline, which can affect energy, cellular health, and overall vitality. Additional lifestyle stressors also further deplete NAD+, such as excessive alcohol consumption, excessive UV exposure, poor sleep, overtraining, as well as a sedentary lifestyle.

That’s where Tru Niagen, a premium, science-backed NAD+ supplement, comes in. Our key ingredient, Niagen (nicotinamide riboside) is clinically proven to efficiently increase NAD+ levels within the cell, so you can support healthy aging, energy, and cellular function. Niagen is globally trusted by researchers and professionals, and used in over 60% of all ongoing clinical trials on NR.

Your cells naturally make NAD+ from vitamin B3 precursors found in a balanced diet. Most people get enough to prevent deficiency, but NAD+ levels naturally decline with age (up to 65% between ages 30 and 70), which can affect cellular energy, metabolism, and overall health.

While there isn’t a universal daily requirement, taking a premium NAD+ boosting supplement like Tru Niagen can help support healthy NAD+ levels, supporting cellular function, energy, and healthy aging.

No—research shows that Tru Niagen does not interfere with your body’s natural NAD+ production. Your cells continue to make NAD+ as usual, and Tru Niagen simply provides nicotinamide riboside, a natural precursor, to help support healthy NAD+ levels and maintain cellular energy and function.

Your cells are still in control—they’re just getting a little extra support!

Tru Niagen contains Niagen (nicotinamide riboside, or NR), a patented and clinically studied NAD+ precursor shown to effectively increase NAD+ levels in humans.

NMN (nicotinamide mononucleotide) is another precursor for NAD+. However, preclinical studies show NMN is often converted to NR outside of cells – before absorption, meaning it may not be as effective at supporting NAD+ levels.

Tru Niagen is the most well-studied, science-backed, premium NAD+ supplement with decades of research supporting its safety and efficacy.

Tru Niagen contains Niagen® (nicotinamide riboside, or NR), a patented, clinically studied form of vitamin B3 that works differently from niacin or nicotinamide found in standard supplements. NR is efficiently absorbed by your cells and converted to NAD+, supporting cellular energy, repair, and overall health.

As opposed to Niacin, which is not a good candidate to use at high servings due to causing skin flushing, or NAM, which inhibits sirtuin proteins involved in cellular defense and repair, Tru Niagen is a premium NAD+ supplement trusted for daily cellular support.

No. Our subscriptions save you 20% each month, deliver with free shipping, and can save you time, but you’re never obligated to enroll. Your Tru Niagen NAD+ journey is entirely in your hands.

It depends on your subscription preferences. Plans are either billed per month, every three months, or twice per year. And you can easily update your subscription preferences at any time by logging in to your account or contacting Customer Care. We're here to support you on your NAD+ journey however we can!

Estimated shipping time is 5–7 business days for orders placed within the US. Just one week and you'll be on your NAD+ journey!

It's easy to make updates to your subscription! Simply log in to your account or contact our Customer Care Team. We're here to support you on your NAD+ journey however we can!

Of course! To update your NAD+ supplement subscription frequency, simply log in to your account or contact our Customer Care Team.

You can pause or cancel your Tru Niagen NAD+ supplement subscription at any time by logging into your account or contacting our Customer Care Team.

Health savings accounts (HSA) and flexible spending accounts (FSA) are programs that allow you to set aside pre-tax funds for eligible healthcare expenses. If you're unsure whether you have an HSA or FSA account, check with your employer or insurance company.

Yes, simply select Truemed as your payment option at checkout and use your HSA or FSA card as you would any other credit card. If you prefer, you can also pay with a regular credit card and submit for reimbursement from your HSA/FSA account later—just save your receipt and Letter of Medical Necessity to file your claim.

All subscription purchases must submit for reimbursement.

HSA/FSA is eligible toward all Tru Niagen products, except for Niagen NanoCloud™ sachets.

HSA/FSA accounts allow you to use pre-tax funds to pay for qualified health expenses. Because these funds are pre-tax, you get more purchasing power—rather than paying taxes on income and then spending it on health products, qualified customers can use pre-tax funds to support their cellular health with Tru Niagen.

A Letter of Medical Necessity (LMN) from Truemed can make your Tru Niagen purchase a qualified medical expense—similar to a doctor's visit or prescription. Supplements may qualify as medical expenses when a licensed provider determines they support a patient's health needs. Your Truemed LMN satisfies IRS requirements to make your purchase eligible for HSA/FSA reimbursement.

Your Letter of Medical Necessity is typically approved within 2–5 hours, though it can occasionally take up to 24 hours. Once you submit your LMN and receipt to your HSA/FSA administrator, reimbursement is generally paid out within 2–4 weeks, depending on your administrator.

If you've already received a Letter of Medical Necessity for Tru Niagen products, you don't need to complete Truemed's survey again as long as your letter remains valid. Letters of Medical Necessity are typically valid for 12 months. You will still need to submit your receipts for reimbursement with your HSA/FSA administrator for each purchase.

Yes. You can submit for partial reimbursement. For example, if you purchase Tru Niagen for $100 but only have $60 in your account, you can reimburse $60 with your tax-free funds and pay the remaining $40 as you normally would.

Contact Truemed at support@truemed.com for help troubleshooting the issue. HSA/FSA plan administrators often have specific requirements, so it may be as simple as re-issuing your Letter of Medical Necessity using your administrator's preferred form.

SuppCo is an independent platform that helps supplement users track their supplement routine. SuppCo rates supplement brands and products based on quality and transparency using their TrustScore rating system.

The best way to experience SuppCo is with their companion app, which you can download by searching for SuppCo in your phone’s app store. If you prefer to use a computer, you can also access the SuppCo platform at http://supp.co.

TrustScore is SuppCo’s proprietary supplement quality rating system. It looks at 29 different attributes across supplement manufacturing, testing, and ingredient selection to rate the overall quality of a product. Products are rated on a 10-point scale. You can learn more about how TrustScore is calculated here: https://supp.co/trustscore/about/product-trustscore#howitscalculated

TrustScores are created by SuppCo’s dedicated research team. While brands can provide documentation as inputs to their score, brands do not have influence over the final TrustScore. To-date, SuppCo has scored over 33,000 supplement products from over 900 brands.

If you have questions about a product’s TrustScore, you can reach out to SuppCo’s team at trustscore@supp.co

Products and brands are rated on a 10-point scale based on their ability to deliver against 29 key quality and transparency attributes. A rating of 8 and above means excellent quality. Tru Niagen has a brand TrustScore of 9.92 and ranks in the top 1% of brands scored by SuppCo. You can learn more about how TrustScore is calculated here: https://supp.co/trustscore/about/product-trustscore#howitscalculated