In the quest for optimal cellular health and longevity, one molecule has captured the attention of scientists worldwide: NAD+. This essential coenzyme powers hundreds of biological processes in your body, and maintaining healthy levels is crucial for energy, metabolism, and healthy aging.
That's where Tru Niagen comes in. Powered by patented Niagen®, a form of nicotinamide riboside (NR), it’s one of the most well-researched, efficient NAD+ precursors that is clinically proven to increase NAD+ levels by over 50% with daily supplementation of 300mg, and up to an impressive 150% with a daily serving of 1000mg. But there's a key factor that determines whether you'll experience these benefits: consistency.
Read on to learn more about why taking an NAD-boosting supplement daily is ideal to maintain baseline elevated NAD+ levels, and tips to stay on track.
Understanding NAD+ Levels and Why Consistency Matters
NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme that facilitates approximately 500 enzymatic reactions throughout our cells, organs, and tissues. We need NAD+ for everything from repairing damaged DNA and pumping blood, to contracting muscles and supporting healthy neuronal activity.
Unfortunately, our NAD+ levels naturally decline with age—dropping as much as 65% between age 30 and 70. This decline is primarily due to cellular damage that accumulates with age and continuous exposure to metabolic stressors such as immune challenges, poor diet, and excessive sun exposure.. With this significant reduction comes signs of age-related physiological decline that can begin to manifest internally as cellular dysfunction.
This is where consistent supplementation with a science-backed, clinically proven, quality-tested NAD+ precursor like Tru Niagen® becomes essential. Each serving of Tru Niagen provides your body with nicotinamide riboside (NR), a precursor that helps replenish your NAD+ stores. But here's the important part: NAD+ is continually in flux, being produced and consumed based on the body’s needs, therefore it’s not stored long-term.
Think of your NAD+ levels like a bathtub with a slow drain. Each serving of Tru Niagen adds more water to the tub, but without regular refilling, the levels gradually decrease. Consistent daily supplementation helps maintain your NAD+ levels, ensuring your cells have the resources they need to function at their best.
The Science Behind Consistent NAD+ Supplementation
Research shows that consistent NR supplementation effectively elevates and maintains NAD+ levels. In a clinical study published in Scientific Reports chronic nicotinamide riboside supplementation was well-tolerated and successfully elevated NAD+ in healthy middle-aged and older adults.
When you take Tru Niagen sporadically, your NAD+ levels may not be elevated past baseline levels. This inconsistency means you might not experience the benefits that steady NAD+ levels can provide.
Benefits of Maintaining Steady NAD+ Levels
Consistent Tru Niagen supplementation helps maintain NAD+ levels, which supports:
1. Optimized Cellular Energy Production
NAD+ is absolutely central to energy metabolism, facilitating processes that turn the carbohydrates, fats, and proteins we eat into energy that our cells can use. Steady NAD+ levels help ensure your mitochondria—the powerhouses of your cells—can efficiently produce the energy your body needs daily.
2. Ongoing Support for Metabolic Health
Metabolic health describes how well your body regulates processes including blood sugar, cholesterol, insulin, body fat, muscle mass, and blood pressure regulation. All of these factors can play a role in how you feel day-to-day—as well as affect long-term health.
3. Continuous DNA Repair
With low NAD+, signs of age-related physiological decline can accelerate. Maintaining your NAD+ levels is a core component of healthy aging. Regular supplementation combined with a healthy lifestyle provides your cells with the resources they need to continuously repair DNA damage that can naturally occur over time.
4. Sirtuin Activation
Sirtuins, a family of enzymes that rely on NAD+ to function properly, are an important component of metabolic health. Many sirtuins, especially SIRT1 and SIRT3, help control processes like glucose balance, lipid and cholesterol metabolism, and mitochondrial function.
Building Your Tru Niagen Routine: Practical Tips for Consistency
Knowing that consistency is key, here are a few ideas to help you make Tru Niagen a seamless part of your daily routine:
1. Pair With an Existing Habit
One of the most effective ways to build a new habit is to connect it to an existing one. Luckily, you do not need to take Tru Niagen with a meal, so you have options! One note about sleep cycles; our circadian rhythm (CR) gets disrupted, which also needs to be addressed. What you may not know is CR encompasses all physical, mental, and behavioral changes that follow a daily cycle.
We know that NAD+ declines with age, and cellular research shows CR vibrations can weaken with age [Sato et al., 2017]. Inside cells, NAD+ levels are influenced by the cellular clock, and NAD+ can regulate the activity of the clock by influencing CR genes.
Here’s some tips on when to take your Tru Niagen to build a routine:
- With your first glass of water for the day
- With your morning coffee, tea, or breakfast
- As part of your daily vitamin/supplement routine
- With a timer set at the same time each day
- In the evening before or after dinner
2. Create Visual Reminders
- Keep your Tru Niagen bottle in an easy-to-reach, highly visible location you pass by daily
- Use a weekly pill organizer placed somewhere prominent, like your nightstand, medicine cabinet, work bag, gym bag, or desk
- Place a small reminder note on your bathroom mirror or refrigerator
- Set your bottle next to items you use every morning (espresso machine, supplement cabinet, water pitcher)
3. Have a Little Extra on Hand
- Keep a small supply in multiple locations (home, office, travel bag)
- Set up auto-delivery to ensure you never run out
- Pack extra when traveling. You never know when you’ll need an extra NAD+ boost!
- If you don’t have a subscription, set a reminder to reorder when your supply gets low
4. Track Your Consistency
NAD+ works at the cellular level, and everyone's experience can be different. Keeping a simple journal or tracker can help you:
- Track when you take Tru Niagen (time of day)
- Note your supplementation amount
- Record benefits you observe when you increase your serving
- Document any patterns you notice when taking it with different foods or other supplements
- Monitor your individual response over time
- If you happen to stop supplementing, monitor any changes you may experience
This tracking helps you understand your personal supplementation patterns and can be valuable information to share with healthcare providers about your regimen.
The Quality Difference: Why Tru Niagen Matters
A recent comprehensive industry analysis conducted by the reference standards and research leg of our parent company, Niagen Bioscience, revealed some alarming findings about the NR supplement market. Their research showed that only 13% of nicotinamide riboside (NR) dietary supplements tested actually meet or exceed their label claims - with Tru Niagen being among those few high-quality products.
The analysis identified concerning patterns across the industry. High water-content “liposomal” NR products (softgels, gummies, and liquids) performed especially poorly, and many products with the highest advertised servings contained virtually no detectable NR. Even some popular, top-selling brands consistently failed testing.
These findings demonstrate that consumers seeking NR's benefits may be receiving dramatically less active ingredient than expected—or in many cases, none at all.
This makes choosing a trusted, third-party verified, rigorously lab-tested, science-backed, high-quality brand like Tru Niagen even more important for ensuring you're actually getting the NR and NAD+ boost your body needs.
To protect yourself further, avoid counterfeiters by purchasing Tru Niagen only from verified sources—either directly from our Tru Niagen website, through authorized Tru Niagen retailers, or from the official Amazon store where products are "Sold by: Tru Niagen" and "Ships from Amazon."
Your Long-Term Commitment to Cellular Health
Essentially, with NAD+ depletion, all of our cells, and organelles involved with energy metabolism can begin to run at suboptimal levels, which may lead to metabolic dysfunction and could affect organs with high energy demands such as your heart, brain, and muscles.
By committing to taking an NAD+ booster like Tru Niagen daily, you're making a long-term investment in your cellular health and metabolic health. While some benefits may be noticeable within weeks, the most significant advantages come from maintaining healthy NAD+ levels over time.
Remember that cellular health is a marathon, not a sprint. Your daily Tru Niagen supplement is working behind the scenes to support the foundational processes that keep your body functioning optimally. That consistency today helps support better health tomorrow.
Making Tru Niagen a Non-Negotiable Part of Your Health Routine
The evidence is clear: NAD+ is crucial for cellular health, NAD+ levels decline as we age, and consistent supplementation with high-quality NR like Tru Niagen is one of the most effective ways to support healthy NAD+ levels.
Your commitment to taking Tru Niagen daily isn't just another item on your to-do list—it's part of your foundational wellness routine for supporting everything from energy production to DNA repair.
So place your Tru Niagen where you'll see it daily, set those reminders, and make it part of your non-negotiable health routine. Your cells will thank you for years to come.
References:
Cantó, C., et al. (2012). The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metabolism, 15(6), 838-847.
Conze, D., Brenner, C., & Kruger, C.L. (2019). Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults. Scientific Reports, 9(1), 9772.
Ramsey, K.M., et al., Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science, 2009. 324(5927): p. 651-4.
Nakahata, Y., et al., Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science, 2009. 324(5927): p. 654-7.
Asher, G., et al., SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell, 2008. 134(2): p. 317-28
Levine DC, Hong H, Weidemann BJ, Ramsey KM, Affinati AH, Schmidt MS, Cedernaes J, Omura C, Braun R, Lee C, Brenner C, Peek CB, Bass J. NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging. Mol Cell. 2020 Jun 4;78(5):835-849.e7. doi: 10.1016/j.molcel.2020.04.010. Epub 2020 May 4. PMID: 32369735; PMCID: PMC7275919.